Season 10 begins with Sam’s frantic search for his missing brother, who is gone without a trace. The road to recovering the wayward Dean takes Sam down dark paths, with consequences that will shake the boys to their core. Meanwhile, Castiel has to pick up the pieces in the aftermath of Metatron’s campaign. With his grace failing and rogue angels still on the loose, Cas will face the ticking clock of his own mortality as all-new threats emerge to once again push all of our heroes to their limits.
Dean is a demon and running amuck with Crowley while Sam tries to figure out what happened to his brother. Meanwhile, Castiel is dealing with his fading grace.
Crowley is worried that Dean, driven by the mark, is getting out of control. Sam struggles to escape from Cole. Hannah tries to convince Metatron to give Castiel his grace back.
Sam continues to try to save Dean from the Mark of Cain. Realizing that Dean's antics are causing problems for him in hell, Crowley seeks help from a reluctant Castiel.
After Dean hears a surprising message on Bobby's phone, he and Sam head out to investigate.
Sam and Dean discover a group of witches on a gone wild trip and attempt to stop them.
Sheriff Jody Mills is matched with an overeager partner during a mandatory sheriff's retreat and when a gruesome corpse is discovered, Jody calls Sam and Dean to help investigate.
Castiel finds Jimmy’s daughter Claire in a group home and she convinces him to break her out. After she runs away from him, Castiel calls Sam and Dean to help find her before she g...
After the massacre at the ranch, Dean, Sam, and Castiel double their efforts to find a cure for the Mark of Cain. Desperate, Castiel comes up with an idea that Sam deems the single...
Sam is scanning the internet for suspicious paranormal activity and comes across a video of Charlie beating up a district attorney. Dean suspects she’s back from Oz and hunting on ...
Looking to get Dean out of the bunker, Sam finds a case for him and Dean to investigate – people are disappearing into thin air with only their clothes left behind.
A ghost starts killing people through various electronic devices. Sam and Dean discover who was killed and why this ghost is seeking revenge on a group of college students but what...
Dean, Sam and Castiel deal with Cain’s return. Crowley and Rowena continue to grow closer but when Crowley bails on plans with his mother to help the Winchesters, Rowena lets him ...
Despite Dean's directive to forget about looking for a cure for the Mark of Cain, Sam continues to do research. Dean suspects Sam is hiding something but decides to focus on a new ...
Sam and Dean investigate a string of suicides committed by people with little in common other than the identical, grisly method of death – slow, self-administered disembowlment. Al...
Sam and Castiel follow up on a lead about the Mark of Cain. Dean and Rowena meet.
Charlie calls Sam and Dean to tell them she found the Book of the Dead which could help remove the Mark of Cain. The Winchesters race to her after she tells them she’s been shot by...
Sam learns that former Men of Letters, Magnus, once built a magical box and Sam sets out to find it in the hopes it can cure Dean of the Mark of Cain. However, what he’s not prepa...
When Claire Novak gets a lead on her mother, Amelia, who has been missing for years, Castiel asks Sam and Dean to help her. However, when they find out what took Amelia, they reali...
Dean and Sam investigate a bizarre murder and realize the killer bears the same tattoo as those from the Styne family. Meanwhile, Castiel acts as referee when Charlie and Rowena ar...
When it comes to the Stynes, Dean decides to take matters into his own hands. Sam tries to come to terms with his decision.
Dean makes a shocking decision regarding the Mark of Cain that would change not only his life, but Sam’s too. Meanwhile, Crowley and Rowena face off and Castiel gets caught in the ...